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The endogenous GSH could trigger the release of NO and active Pt (II) from SPNA simultaneously (Figures 3E, F), thereby generating highly toxic peroxynitrite anion (ONOO )

While tirzepatide slows gastric emptying and reduces caloric intake through incretin receptor activation, 5-amino-1MQ works intracellularly to inhibit nicotinamide N-methyltransferase (NNMT), shifting cellular metabolism toward fat oxidation independent of appetite suppression